Description

1-Hydroxy-22-Oxavitamin D3 is a synthetic vitamin D3 analog, representing a key intermediate in the research and development of novel calcitriol-related compounds. This compound matters for its role in studying the structure-activity relationships of vitamin D metabolites and their receptor interactions. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing new therapeutic agents for conditions related to calcium metabolism and cell differentiation.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced vitamin D analogs for preclinical and clinical research.
• Biochemical Research: Used as a reference standard or probe in studies investigating the vitamin D endocrine system, receptor binding, and metabolic pathways.
• Drug Discovery: Serves as a precursor for creating new chemical entities targeting vitamin D receptor (VDR) for potential treatments of osteoporosis, psoriasis, and certain cancers.
• Academic Studies: Employed in university and institutional labs for fundamental research on sterol chemistry and hormone action.
• Fine Chemical Synthesis: Used by custom synthesis and contract manufacturing organizations (CMOs) to produce specialized, high-value compounds for clients.

Basic Information

Product Name	1-Hydroxy-22-Oxavitamin D3
CAS No.	111687-67-3
Molecular Formula	C27H42O3
Molecular Weight	414.62 g/mol
Synonyms	1α-Hydroxy-22-oxavitamin D3; 1α-Hydroxy-22-oxocholecalciferol; 22-Oxo-1α-hydroxyvitamin D3; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,22-triol; 22-Oxocalcitriol precursor; Vitamin D3 analog intermediate
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-22-Oxavitamin D3 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.