Description

2-Azetidinone, 4-Ethynyl-3-(1-Hydroxyethyl)-, [3S-[3Alpha(S*),4Beta]]- (9Ci) is a specialized β-lactam derivative, a key structural motif in medicinal chemistry. This compound matters as a high-value chiral building block for the synthesis of novel pharmaceutical agents, particularly in the development of enzyme inhibitors and targeted therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced drug discovery and process chemistry for creating next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new β-lactam-based drugs and enzyme inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex target molecules in pilot plants.
• Academic Research: Utilized in universities and institutes for studying stereoselective synthesis and reaction mechanisms involving strained heterocycles.
• Bioconjugation Chemistry: The ethynyl group provides a handle for click chemistry applications, useful in probe and linker development.

Basic Information

Product Name	2-Azetidinone, 4-Ethynyl-3-(1-Hydroxyethyl)-, [3S-[3Alpha(S*),4Beta]]- (9Ci)
CAS No.	111408-23-2
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	(3S,4R)-4-Ethynyl-3-(1-hydroxyethyl)azetidin-2-one; 4-Ethynyl-3-(1-hydroxyethyl)-2-azetidinone, (3S,4R)-; [3S-[3α(S*),4β]]-4-Ethynyl-3-(1-hydroxyethyl)-2-azetidinone; (3S,4R)-3-[(1S)-1-Hydroxyethyl]-4-ethynylazetidin-2-one; Azetidin-2-one, 4-ethynyl-3-(1-hydroxyethyl)-, (3S,4R)-; β-lactam derivative with ethynyl and hydroxyethyl substituents; Chiral β-lactam building block
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), tailored to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request. Production can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.