Description

Pioglitazone is a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), primarily used as an active pharmaceutical ingredient (API). This compound is critical for the development and manufacture of type 2 diabetes medications, helping to improve glycemic control by increasing insulin sensitivity in peripheral tissues. It is essential for pharmaceutical manufacturers and research institutions focused on metabolic disorder therapeutics and drug discovery programs.

Application

• Pharmaceutical API: Primary use as the active ingredient in anti-diabetic medications for the treatment of type 2 diabetes mellitus.
• Formulation Development: Used in R&D for developing various oral dosage forms, including tablets and combination drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: A key tool for studying PPARγ receptor pathways, insulin resistance mechanisms, and adipocyte differentiation.
• Preclinical Studies: Utilized in animal model research to investigate pharmacokinetics, efficacy, and safety profiles of thiazolidinedione-class drugs.
• Generic Drug Manufacturing: Critical for companies producing generic versions of branded pioglitazone medications.

Basic Information

Product Name	Pioglitazone
CAS No.	111025-46-8
Molecular Formula	C19H20N2O3S
Molecular Weight	356.44 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; AD-4833; U-72107A; Actos (brand name); Pioglitazone Hydrochloride (salt form); Glustin; Zactos; TZD Derivative
EINECS	Contact for details

Quality Control

Our Pioglitazone is manufactured and tested under strict quality systems. We ensure compliance with ICH guidelines and relevant pharmacopeial standards for active pharmaceutical ingredients. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, protect from moisture. Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.