Description

Insulin, Asp(B9)-Glu(B27)- is a synthetic, site-specifically modified insulin analogue, identified by CAS NO 110734-38-8. This engineered peptide is of significant interest in pharmaceutical research for its altered receptor binding kinetics and metabolic stability compared to native human insulin. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for researchers and manufacturers developing next-generation diabetes therapeutics and studying insulin signaling pathways.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the production of insulin-based drugs.
• Biomedical Research: A key tool for in vitro and in vivo studies investigating the structure-activity relationship (SAR) of insulin and its analogues.
• Drug Discovery & Development: Serves as a precursor or intermediate in the synthesis of novel, fast-acting or basal insulin formulations.
• Metabolic Disorder Studies: Employed in research focused on insulin resistance, diabetes mellitus, and related metabolic pathways.
• Biochemical Assays: Used in receptor binding assays, cell-based potency tests, and other functional characterizations.

Basic Information

Product Name	Insulin, Asp(B9)-Glu(B27)-
CAS No.	110734-38-8
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Insulin Aspart (B9, B27 variant); Insulin X14; [AspB9, GluB27]-Insulin; Insulin analogue (AspB9, GluB27); B9-Asp-B27-Glu-Insulin; Human Insulin (Asp(B9), Glu(B27)); Modified Insulin Peptide; Insulin Derivative (110734-38-8)
EINECS	Contact for details

Quality Control

Our Insulin, Asp(B9)-Glu(B27)- is produced and handled under strict quality management systems. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity and identity confirmation, to ensure it meets rigorous research and development standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 10.0%
Peptide Content	≥ 80.0%
Biological Activity	Assessed by cell-based assay (Data available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.