Description

Insulin, Despentapeptide (B26-B30)-Hisnh2(B25)- is a synthetic, biologically active insulin analogue with a specific modification to its B-chain, designed for advanced research and development applications. This high-purity peptide is critical for studying insulin signaling pathways, receptor binding kinetics, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic disease research and next-generation diabetes treatments.

Application

• Pharmaceutical Research & Development: As a key reference standard and active ingredient in the development of novel insulin analogues and diabetes therapeutics.
• Biochemical Assay Development: For use in receptor binding studies, cell-based assays, and high-throughput screening to evaluate insulin activity and potency.
• Metabolic Disease Studies: Fundamental research into insulin action, glucose metabolism, and the pathophysiology of diabetes and related disorders.
• Structure-Activity Relationship (SAR) Analysis: To investigate the impact of specific peptide chain modifications on biological function and stability.
• Quality Control & Analytical Standard: Serves as a certified reference material (CRM) for the identification and quantification of insulin-related compounds in analytical methods like HPLC and mass spectrometry.

Basic Information

Product Name	Insulin, Despentapeptide (B26-B30)-Hisnh2(B25)-
CAS No.	110353-31-6
Molecular Formula	C254H377N65O76S6
Molecular Weight	5807.4 g/mol
Synonyms	Despentapeptide(B26-B30) Insulin; [His(B25)NH2, Despentapeptide(B26-B30)]-Insulin; Insulin (human) [His(B25)NH2, Despentapeptide(B26-B30)]; Insulin analogue (B25-His-NH2, des-(B26-B30)); B25-Histidine Amide, Des-(B26-B30)-Insulin; Modified Insulin B-Chain; Insulin B-Chain Analogue
EINECS	Contact for details

Quality Control

Our Insulin, Despentapeptide (B26-B30)-Hisnh2(B25)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to primary reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.