Description

4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Dihydrochloride is a high-purity, pharmaceutically relevant piperazine derivative supplied as a dihydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the research and synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing central nervous system (CNS) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthesis processes for final active compounds.
• Biochemical Research: Employed in pharmacological studies to investigate receptor interactions and biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Dihydrochloride
CAS No.	109806-71-5
Molecular Formula	C19H23ClN2O • 2HCl
Molecular Weight	407.77 g/mol (Free base: 330.85 g/mol)
Synonyms	1-Piperazineethanol, 4-[(4-chlorophenyl)phenylmethyl]-, dihydrochloride; Cetirizine Impurity; (4-Chlorobenzhydryl)piperazin-1-yl-ethanol dihydrochloride; Levocetirizine Related Compound; Zyrtec Intermediate; 4-[(p-Chloro-α-phenylbenzyl)]-1-piperazineethanol dihydrochloride; 109806-71-5
EINECS	Contact for details

Quality Control

Our 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Dihydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by IR and NMR. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.