Description

2(S)-Aza-Bicyclo[2.2.2]Octane-2,3-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, chiral bicyclic building block of significant importance in advanced organic synthesis. This compound is valued for its rigid, three-dimensional structure, which is instrumental in constructing complex molecules with precise stereochemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and catalyst development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in developing central nervous system (CNS) active compounds and enzyme inhibitors.
• Asymmetric Catalysis: Serves as a precursor or ligand framework for chiral catalysts used in enantioselective synthesis.
• Agrochemical Research: Used in the development of new, stereochemically defined active ingredients for crop protection.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable tool for methodological development in organic chemistry and for exploring new chemical space in discovery programs.

Basic Information

Product Name	2(S)-Aza-Bicyclo[2.2.2]Octane-2,3-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	109523-16-2
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	(2S)-2-(tert-Butoxycarbonyl)-2,3-diazabicyclo[2.2.2]octane-3-carboxylic acid; (2S)-3-(tert-Butoxycarbonyl)-2,3-diazabicyclo[2.2.2]octane-2-carboxylic acid; 2(S)-N-Boc-2,3-diazabicyclo[2.2.2]octane-3-carboxylic acid; 2(S)-Aza-Bicyclo[2.2.2]Octane-2,3-Dicarboxylic Acid 2-tert-Butyl Ester; (2S)-2-[(tert-Butoxy)carbonyl]-2,3-diazabicyclo[2.2.2]octane-3-carboxylic acid; 2(S)-Boc-2,3-DABCO-3-COOH; tert-Butyl (2S)-3-carboxy-2,3-diazabicyclo[2.2.2]octane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 2(S)-Aza-Bicyclo[2.2.2]Octane-2,3-Dicarboxylic Acid 2-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.