Description

5-Fluoro-12-Hydroxyeicosatetraenoic Acid is a fluorinated derivative of the hydroxyeicosatetraenoic acid (HETE) family, a class of bioactive lipid mediators. This specialized compound is valued for its role as a potent and selective biochemical tool in pharmacological and metabolic research. It is primarily sought by researchers and developers in the pharmaceutical and biotechnology sectors for investigating eicosanoid signaling pathways, enzyme inhibition studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard and a selective probe in studies of lipoxygenase (LOX) and cytochrome P450 enzyme pathways.
• Pharmacology Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the research and development of anti-inflammatory and metabolic disorder therapeutics.
• Cell Signaling Studies: Employed to investigate the role of fluorinated eicosanoids in cellular communication, inflammation, and immune response mechanisms.
• Metabolite Analysis: Acts as a critical analytical standard in mass spectrometry (LC-MS/MS) and chromatography (HPLC) for the quantification of HETE metabolites in biological samples.
• Enzyme Inhibition Assays: Utilized to study and characterize the inhibition kinetics of 12-lipoxygenase and related enzymes.

Basic Information

Product Name	5-Fluoro-12-Hydroxyeicosatetraenoic Acid
CAS No.	109522-29-4
Molecular Formula	C₂₀H₃₁FO₄
Molecular Weight	354.46 g/mol
Synonyms	5-F-12-HETE; 5-Fluoro-12-HETE; 5-Fluoro-12(S)-HETE; 12-Hydroxy-5-fluoroeicosa-6Z,8E,10E,14Z-tetraenoic acid; 5-Fluoro-12-hydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 5-Fluoro-12(S)-hydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 5-F-12(S)-HETE; 5-Fluoro-12-hydroxyeicosa-6Z,8E,10E,14Z-tetraenoic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-12-Hydroxyeicosatetraenoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify stereochemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95% (Area %)
Chiral Purity	≥ 98% (12(S)-enantiomer)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.