Description

12(R)-Hepe is a specialized, high-purity eicosapentaenoic acid (EPA) derivative, specifically the 12(R)-hydroxy form, with the CAS registry number 109430-12-8. This compound is a valuable bioactive lipid mediator and synthetic intermediate, prized for its role in specialized resolution pathways and as a building block for advanced pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, nutraceutical, and advanced chemical synthesis sectors who require high-quality, well-characterized reference standards and intermediates.

Application

• Pharmaceutical Research & Development: As a key reference standard and intermediate in the study of specialized pro-resolving mediators (SPMs) and inflammation resolution pathways.
• Bioactive Lipid Synthesis: A crucial precursor for the chemical and enzymatic synthesis of more complex resolvins and other oxylipin signaling molecules.
• Biochemical Assays: Used in cell culture studies and in vitro assays to investigate the biological effects of 12(R)-HETE and related eicosanoids.
• Nutraceutical Advanced Research: Employed in high-end research exploring novel, potent derivatives of ω-3 fatty acids with targeted biological activities.
• Analytical Standard: Serves as a high-purity calibration standard for analytical methods such as LC-MS, HPLC, and GC-MS in metabolomics and lipidomics.

Basic Information

Product Name	12(R)-Hepe
CAS No.	109430-12-8
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	12(R)-HETE; 12(R)-Hydroxyeicosatetraenoic Acid; (12R)-HETE; 12R-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic Acid; 12(R)-HepE; 12R-HEPE; 12(R)-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 12R-Hydroxyicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Every batch of 12(R)-Hepe is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chiral HPLC and spectroscopic analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is easily oxidized and should be handled in a controlled environment to minimize exposure to air. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
Chiral Purity (Chiral HPLC)	≥ 98% (12R)
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.