Description

2-Oxopentanedioic Acid-13C1 is a stable isotope-labeled analog of 2-oxoglutaric acid, where one carbon atom is replaced by the carbon-13 isotope. This precise labeling is critical for applications requiring high sensitivity and specificity in metabolic pathway tracing and quantitative analysis. It is an essential biochemical tool for researchers and developers in the fields of pharmaceutical research, clinical diagnostics, and advanced metabolomics studies.

Application

• As an internal standard for the accurate quantification of 2-oxoglutarate in biological samples via LC-MS (Liquid Chromatography-Mass Spectrometry) and GC-MS (Gas Chromatography-Mass Spectrometry).
• Tracer compound in metabolic flux analysis to study the Krebs cycle, amino acid metabolism, and other central biochemical pathways.
• Key reagent in the development and validation of clinical diagnostic assays for inborn errors of metabolism and other metabolic disorders.
• Used in pharmaceutical research for investigating drug mechanisms of action that involve modulation of α-ketoglutarate-dependent dioxygenases.
• Essential component in isotope dilution mass spectrometry methods to ensure high accuracy and precision in research data.
• Substrate or standard in enzymatic activity assays for dehydrogenases and transaminases.

Basic Information

Product Name	2-Oxopentanedioic Acid-13C1
CAS No.	108395-15-9
Molecular Formula	C413C1H6O5
Molecular Weight	147.09 g/mol (for 13C1 labeled form)
Synonyms	2-Oxoglutaric Acid-13C1; α-Ketoglutaric Acid-13C1; 2-Ketoglutaric Acid-13C1; 2-Oxopentanedioic Acid-1-13C; Oxoglutaric Acid-13C1; 2-Oxo-1,5-pentanedioic Acid-13C1
EINECS	Contact for details

Quality Control

Every batch of 2-Oxopentanedioic Acid-13C1 is manufactured and tested under a strict quality management system. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment, and identification. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.