Description

Glidobactin A CAS NO 108351-50-4 is a potent, naturally occurring proteasome inhibitor belonging to the glidobactin class of non-ribosomal peptides. This compound matters for its significant role as a biochemical tool in life science research, particularly in the study of cellular protein degradation pathways and apoptosis. It is primarily needed by research institutions and pharmaceutical R&D departments focused on oncology, neurobiology, and the development of novel therapeutic agents targeting the ubiquitin-proteasome system.

Application

• Biochemical Research: Used as a highly specific inhibitor of the 20S proteasome's chymotrypsin-like activity for mechanistic studies in cell biology.
• Pharmaceutical R&D: Serves as a lead compound or reference standard in drug discovery programs targeting proteasome function for cancer and inflammatory diseases.
• Cell Signaling Studies: Employed to investigate the role of protein degradation in NF-κB signaling and other critical cellular pathways.
• Apoptosis Research: A key tool for inducing programmed cell death in experimental models to study cancer cell vulnerability.
• Reference Standard: Used in analytical laboratories for method development, calibration, and quality control of related compounds.
• Enzyme Inhibition Assays: Applied in high-throughput screening (HTS) to identify and characterize new proteasome inhibitors.

Basic Information

Product Name	Glidobactin A
CAS No.	108351-50-4
Molecular Formula	C₃₄H₆₀N₈O₈
Molecular Weight	696.90 g/mol
Synonyms	Glidobactin A; Cystargolide; Glidobactin; Syringolin A analog; Proteasome inhibitor Glidobactin A; (3S,6S,9S,12S,15S,18S,21S,24S)-3-[(2S)-Butan-2-yl]-6,9,12,15,18,21,24-heptaisobutyl-1,4,7,10,13,16,19,22-octaoxo-27-thia-2,5,8,11,14,17,20,23-octaazatricyclo[24.3.0.0³,²⁷]nonacosane-26-carboxylic acid
EINECS	Contact for details

Quality Control

Our Glidobactin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment to support your compliance and research integrity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.