Description

Diethyl(Troc-Aminomethyl)Phosphonate is a specialized organophosphorus compound featuring a trichloroethoxycarbonyl (Troc)-protected aminomethyl group. This unique structure makes it a valuable building block in synthetic organic chemistry, particularly for the controlled introduction of phosphorus and amine functionalities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of complex drug molecules, particularly those requiring phosphonate or modified amino acid motifs.
• Peptide Mimetics & Prodrug Synthesis: Used to create phosphonate-based isosteres of amino acids and to construct prodrug linkages for improved bioavailability.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, insecticides, and plant growth regulators with phosphonate backbones.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphonate-containing ligands for metal catalysis and organocatalysis.
• Material Science: Used in the synthesis of functionalized monomers for specialty polymers and surface-modifying agents.
• Chemical Biology Probes: Acts as a building block for creating activity-based probes and enzyme inhibitors targeting phosphatases and other enzymes.

Basic Information

Product Name	Diethyl(Troc-Aminomethyl)Phosphonate
CAS No.	108183-45-5
Molecular Formula	C8H16Cl3NO5P
Molecular Weight	352.55 g/mol
Synonyms	Diethyl [(2,2,2-Trichloroethoxycarbonylamino)methyl]phosphonate; (Troc-Aminomethyl)phosphonic Acid Diethyl Ester; Diethyl N-[(Troc)aminomethyl]phosphonate; Diethyl P-[(Troc-amino)methyl]phosphonate; Phosphonic acid, P-[[(2,2,2-trichloroethoxy)carbonyl]amino]methyl]-, diethyl ester; Troc-NH-CH2-P(O)(OEt)2
EINECS	Contact for details

Quality Control

Our Diethyl(Troc-Aminomethyl)Phosphonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.