Description

(E)-2-[n-[(2S)-2,3-Dihydroxy-1-Oxopropyl]Glycylamino]-n-[(3R)-2-Oxo-1-Sulfo-3-Azetidinyl]-2-Butenediamide is a high-purity, advanced pharmaceutical intermediate with a complex molecular architecture. This compound is critical for the synthesis of novel β-lactam antibiotics and other specialized therapeutic agents, offering researchers and manufacturers a reliable building block for complex chemical transformations. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and antibiotic development.

Application

• Key Intermediate in β-Lactam Antibiotic Synthesis: Serves as a crucial precursor in the development of next-generation penicillin and cephalosporin analogs with enhanced efficacy.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and the discovery of new antimicrobial agents.
• Fine Chemical Manufacturing: Employed in multi-step synthetic routes for producing high-value, target-specific active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating enzyme inhibition, particularly those involving bacterial cell wall synthesis enzymes.
• Process Development & Scale-Up: Supports process chemistry teams in optimizing synthetic routes from laboratory to pilot and commercial scale.

Basic Information

Product Name	(E)-2-[n-[(2S)-2,3-Dihydroxy-1-Oxopropyl]Glycylamino]-n-[(3R)-2-Oxo-1-Sulfo-3-Azetidinyl]-2-Butenediamide
CAS No.	108065-96-9
Molecular Formula	C12H16N4O10S
Molecular Weight	408.34 g/mol
Synonyms	N-[(2S)-2,3-Dihydroxy-1-oxopropyl]-N-[(3R)-2-oxo-1-sulfo-3-azetidinyl]glycylamino-(E)-2-butenediamide; (E)-2-((S)-2,3-Dihydroxypropanamido)-N-((R)-2-oxo-1-sulfoazetidin-3-yl)-2-butenamide; Glycine, N-[(1S)-1,2-dihydroxy-2-oxoethyl]-, 2-[(1E)-1,2-dicarboxyethenyl]amino-1-[(3R)-2-oxo-1-sulfo-3-azetidinyl]amide; Aztreonam derivative intermediate; β-Lactam sulfonate intermediate; Monosulfactam intermediate
EINECS	Contact for details

Quality Control

Our (E)-2-[n-[(2S)-2,3-Dihydroxy-1-Oxopropyl]Glycylamino]-n-[(3R)-2-Oxo-1-Sulfo-3-Azetidinyl]-2-Butenediamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.