Description

Cilastatin Sodium CAS NO 107872-24-2 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) primarily used as a renal dehydropeptidase inhibitor. It is critically important for its role in combination therapies, where it prevents the renal metabolism of certain β-lactam antibiotics, thereby increasing their efficacy and duration of action. This compound is essential for manufacturers in the pharmaceutical industry developing and producing advanced antibiotic formulations, particularly for hospital and critical care settings.

Application

• Pharmaceutical API: Key component in combination injectable antibiotic drugs, such as those containing imipenem.
• Renal Dehydropeptidase Inhibitor: Specifically formulated to protect carbapenem-class antibiotics from degradation in the kidneys.
• Critical Care Medicine: Used in the manufacture of broad-spectrum antibiotics for treating severe, hospital-acquired infections.
• Antibiotic Potentiator: Enhances the pharmacokinetic profile and therapeutic effectiveness of co-administered antibiotics.
• Research & Development: Serves as a reference standard and building block in antimicrobial research and new drug development.
• Veterinary Pharmaceuticals: Employed in advanced antibiotic treatments for animals.

Basic Information

Product Name	Cilastatin Sodium
CAS No.	107872-24-2
Molecular Formula	C16H25N2NaO5S
Molecular Weight	380.44 g/mol
Synonyms	(Z)-7-[(R)-2-Amino-2-carboxyethylthio]-2-[(S)-2,2-dimethylcyclopropanecarboxamido]hept-2-enoic acid sodium salt; MK-0791 sodium; Sodium cilastatin; Cilastatin (sodium salt); Cilastatin sodium salt; (Z)-7-[(R)-2-Amino-2-carboxyethylthio]-2-[(S)-2,2-dimethylcyclopropanecarboxamido]-2-heptenoic acid sodium salt
EINECS	Contact for details

Quality Control

Our Cilastatin Sodium is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. We ensure rigorous testing for identity, purity, and potency, with processes designed to meet the stringent requirements of cGMP (Current Good Manufacturing Practice) guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Specific Rotation	Contact for details
Bacterial Endotoxins	< 0.17 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.