Description

4,6-Dichloronicotinoyl Chloride is a versatile and highly reactive chemical intermediate, primarily valued for its role as a key building block in advanced organic synthesis. Its bifunctional chloronicotinoyl structure makes it indispensable for constructing complex heterocyclic frameworks and introducing specific functional groups. This compound is critically needed by research and development chemists, as well as process development teams, in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nicotinic acid derivatives and other heterocyclic compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, insecticides, and fungicides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functional organic molecules for electronic materials, such as organic semiconductors or charge-transport materials.
• Custom Synthesis and Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic and Industrial R&D: Essential for exploratory chemistry in both academic laboratories and corporate R&D centers focused on medicinal chemistry and chemical biology.

Basic Information

Product Name	4,6-Dichloronicotinoyl Chloride
CAS No.	107836-75-9
Molecular Formula	C6H2Cl3NO
Molecular Weight	210.45 g/mol
Synonyms	4,6-Dichloropyridine-3-carbonyl chloride; 3-Pyridinecarbonyl chloride, 4,6-dichloro-; 4,6-Dichloronicotinic acid chloride; 4,6-Dichloronicotinyl chloride; Nicotinoyl chloride, 4,6-dichloro-; 4,6-Dichloro-3-pyridinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 4,6-Dichloronicotinoyl Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.