Description

Rac-4'-Methyl Ketoprofen CAS NO 107257-20-5 is a methylated derivative of the well-known non-steroidal anti-inflammatory drug (NSAID) ketoprofen, serving as a key chiral intermediate and reference standard in pharmaceutical research and development. This compound is of significant value for investigating structure-activity relationships (SAR), metabolic pathways, and for the synthesis of novel anti-inflammatory agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemists, and manufacturers of active pharmaceutical ingredients (APIs) who require high-purity building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis and process development of novel NSAID derivatives and prodrugs.
• Analytical Reference Standard: Used in method development and validation for HPLC, LC-MS, and other chromatographic techniques to quantify ketoprofen and its metabolites in biological and pharmaceutical matrices.
• Metabolic Studies: Employed in preclinical and clinical research to study the pharmacokinetics, metabolism, and bioavailability of methylated ketoprofen analogs.
• Structure-Activity Relationship (SAR) Research: Essential for medicinal chemistry programs aiming to modify the ketoprofen scaffold to enhance potency, selectivity, or reduce side effects.
• Impurity Standard: Serves as a certified reference material (CRM) for identifying and controlling potential impurities or degradants in ketoprofen API manufacturing.

Basic Information

Product Name	Rac-4'-Methyl Ketoprofen
CAS No.	107257-20-5
Molecular Formula	C₁₇H₁₆O₃
Molecular Weight	268.31 g/mol
Synonyms	4'-Methyl Ketoprofen (Racemic); (±)-4'-Methyl Ketoprofen; 2-(3-(4-Methylbenzoyl)phenyl)propanoic Acid; DL-4'-Methyl Ketoprofen; rac-2-(3-(4-Methylbenzoyl)phenyl)propionic Acid; 4'-Methyl-2-(3-benzoylphenyl)propionic Acid (racemic); Ketoprofen, 4'-methyl- (racemic)
EINECS	Contact for details

Quality Control

Our Rac-4'-Methyl Ketoprofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling by advanced techniques like HPLC and NMR, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.