Description

26,27-Dimethyl-24,24-Difluoro-1,25-Dihydroxyvitamin D3 is a potent, fluorinated analog of the active form of Vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol). This compound is engineered for enhanced metabolic stability and targeted biological activity, making it a critical intermediate and reference standard in advanced pharmaceutical research. It is essential for scientists and manufacturers developing novel therapeutics for conditions related to calcium regulation, cell differentiation, and immune modulation.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new Vitamin D receptor (VDR) modulators.
• Metabolic Bone Disease Studies: Used in preclinical research to investigate treatments for osteoporosis, renal osteodystrophy, and other disorders of mineral metabolism.
• Oncology Research: Employed in studies exploring the anti-proliferative and pro-differentiating effects of Vitamin D analogs on various cancer cell lines.
• Dermatology Drug Development: Acts as a precursor in the synthesis of topical treatments for psoriasis and other hyperproliferative skin conditions.
• Immunology Research: Utilized to study the immunomodulatory functions of Vitamin D analogs in autoimmune and inflammatory diseases.
• Chemical Synthesis: A high-value building block for the custom synthesis of other fluorinated and alkylated Vitamin D derivatives.

Basic Information

Product Name	26,27-Dimethyl-24,24-Difluoro-1,25-Dihydroxyvitamin D3
CAS No.	106647-71-6
Molecular Formula	C₂₉H₄₄F₂O₃
Molecular Weight	478.66 g/mol
Synonyms	1,25-Dihydroxy-26,27-dimethyl-24,24-difluorovitamin D3; 24,24-Difluoro-1,25-dihydroxy-26,27-dimethylcholecalciferol; Falecalcitriol analog; 26,27-Dimethyl-24,24-difluoro-calcitriol; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-Ethyl-5-fluoro-1,5-dimethylhex-2-en-1-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 26,27-Dimethyl-24,24-Difluoro-1,25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.