Description

24,24-Difluoro-25-Hydroxy-26,27-Dimethylvitamin D3 is a high-purity, fluorinated analog of vitamin D, designed for advanced research and pharmaceutical development. This compound is valued for its enhanced metabolic stability and targeted biological activity compared to its non-fluorinated counterparts. It is primarily utilized by researchers and manufacturers in the life sciences sector for developing novel therapeutics and conducting in-depth biochemical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation vitamin D receptor (VDR) agonists and modulators for therapeutic applications.
• Biochemical Research: Used as a reference standard and active compound in studies investigating calcium homeostasis, cell differentiation, and immune modulation.
• Metabolic Pathway Analysis: Employed to study the structure-activity relationships (SAR) of vitamin D analogs, particularly the impact of fluorination on metabolic stability and receptor binding.
• Drug Discovery & Development: Serves as a critical starting material or intermediate in R&D pipelines focused on osteoporosis, psoriasis, cancer, and other diseases mediated by vitamin D pathways.
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	24,24-Difluoro-25-Hydroxy-26,27-Dimethylvitamin D3
CAS No.	106647-61-4
Molecular Formula	C29H46F2O2
Molecular Weight	464.68 g/mol
Synonyms	1α,25-Dihydroxy-24,24-difluoro-26,27-dimethylvitamin D3; 1α,25-Dihydroxy-24,24-difluoro-26,27-dimethylcholecalciferol; 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3; Falecalcitriol analog; 24,24-Difluoro-26,27-dimethyl-1α,25-dihydroxycholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol, 24,24-difluoro-26,27-dimethyl-
EINECS	Contact for details

Quality Control

Our 24,24-Difluoro-25-Hydroxy-26,27-Dimethylvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.