Description

4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid, 6-(1-Hydroxyethyl)-7-Oxo-3-(Tetrahydro-2-Furanyl)-, [5R-[3(S*),5α,6α(R*)]]- (9Ci) CAS NO 106560-13-8 is a high-purity, advanced pharmaceutical intermediate characterized by its complex bicyclic β-lactam structure. This compound is of significant value in the research and development of novel antibiotics and other therapeutic agents, serving as a critical building block for synthetic chemists. It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and antimicrobial studies.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a crucial precursor in the multi-step synthesis of novel β-lactam antibiotics and related pharmacologically active molecules.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to develop new antimicrobial agents with improved efficacy and spectrum.
• Process Development & Scale-Up: Employed in pilot plants and kilo-labs for optimizing synthetic routes and developing scalable manufacturing processes for target Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control, method development, and regulatory submissions in pharmaceutical analysis.
• Biochemical Research: Applied in studies investigating the mechanism of action and resistance of β-lactam-based drugs against bacterial enzymes.

Basic Information

Product Name	4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid, 6-(1-Hydroxyethyl)-7-Oxo-3-(Tetrahydro-2-Furanyl)-, [5R-[3(S*),5α,6α(R*)]]- (9Ci)
CAS No.	106560-13-8
Molecular Formula	C12H15NO5S
Molecular Weight	285.32 g/mol
Synonyms	(5R,6R)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; 6-(1-Hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, (5R,6R)-; A β-lactam antibiotic intermediate; Tetrahydrofuranyl penicillinic acid derivative; Penem derivative; 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, (5R,6R)-; [5R-[3(S*),5alpha,6alpha(R*)]]-6-(1-Hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.