Description

2-Chloro-5-(Chloromethyl)Pyrazine is a versatile and highly functionalized pyrazine derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its dual reactive sites—the chloromethyl group and the chloro-substituted aromatic ring—enable precise molecular construction, making it indispensable for creating complex heterocyclic architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used to construct pyrazine-based fungicides, herbicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as conductive polymers and molecular semiconductors.
• Chemical Biology Probes: Utilized to synthesize tagged molecules or affinity probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for fine chemical and custom synthesis houses producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	2-Chloro-5-(Chloromethyl)Pyrazine
CAS No.	105985-21-5
Molecular Formula	C5H4Cl2N2
Molecular Weight	162.00 g/mol
Synonyms	5-(Chloromethyl)-2-chloropyrazine; 2-Chloro-5-chloromethylpyrazine; Pyrazine, 2-chloro-5-(chloromethyl)-; 2,5-Dichloromethylpyrazine (incorrect but common alias); 105985-21-5; 2-Chloro-5-(chloranyl-methyl)pyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Chloromethyl)Pyrazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.