Description

1,2-Distearoyl-Sn-Glycero-3-Phosphatidic Acid Disodium Salt is a high-purity, synthetic phospholipid derivative, specifically a phosphatidic acid salt. This compound is a critical building block in advanced lipid-based formulations, valued for its role in modulating membrane properties and serving as a key intermediate. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors who require precise and reliable lipid components for innovative applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A key anionic lipid component used in the development of mRNA and siRNA delivery systems.
• Liposome & Vesicle Preparation: Employed to create stable, anionic liposomal carriers for drug delivery, diagnostics, and cosmetic applications.
• Biomimetic Membrane Research: Used in model membrane systems (e.g., supported lipid bilayers) to study membrane biophysics, protein-lipid interactions, and signaling pathways.
• Pharmaceutical Intermediates: Serves as a crucial precursor for the synthesis of more complex functionalized phospholipids, such as PEGylated lipids or targeted conjugates.
• Biochemical Research: A standard reagent in enzymatic assays and studies involving phospholipase activity or lipid metabolism.
• Cosmetic Actives: Incorporated into high-end skincare formulations for its emulsifying and skin-barrier enhancing properties.

Basic Information

Product Name	1,2-Distearoyl-Sn-Glycero-3-Phosphatidic Acid Disodium Salt
CAS No.	105405-51-4
Molecular Formula	C39H74Na2O8P
Molecular Weight	747.96 g/mol
Synonyms	1,2-Distearoyl-sn-glycerol-3-phosphate disodium salt; DSPA disodium salt; PA(18:0/18:0) disodium salt; Phosphatidic acid (18:0) disodium salt; 1,2-Di-O-stearoyl-sn-glycero-3-phosphate disodium salt; Distearoyl phosphatidic acid disodium salt; DSPA-Na2; L-α-Phosphatidic acid, distearoyl, disodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Distearoyl-Sn-Glycero-3-Phosphatidic Acid Disodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and cGMP-grade manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The material is hygroscopic and must be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Solubility	Soluble in chloroform, methanol; forms dispersions in water
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.