Description

5-(4-(2-(3-Methylpyridin-2-Yl)Ethoxy)Benzyl)Thiazolidine-2,4-Dione is a high-purity, non-racemic pharmaceutical intermediate of significant commercial and research interest. This compound matters as a key synthetic precursor in the development of novel therapeutic agents, particularly those targeting metabolic disorders. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in advanced synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of thiazolidinedione-based drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in the multi-step production of target APIs.
• Metabolic Disease Research: Applied in the development of compounds for diabetes and related metabolic syndrome research.
• Pre-clinical Studies: Supplied for use in pharmacological and toxicological evaluations of new chemical entities.
• Reference Standard: Sourced for use as an analytical standard in quality control laboratories.

Basic Information

Product Name	5-(4-(2-(3-Methylpyridin-2-Yl)Ethoxy)Benzyl)Thiazolidine-2,4-Dione
CAS No.	105355-33-7
Molecular Formula	C18H18N2O3S
Molecular Weight	342.41 g/mol
Synonyms	5-[[4-[2-(3-Methyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-(4-(2-(3-Methylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; (R)-5-(4-(2-(3-Methylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione (enantiomer); Thiazolidinedione derivative; TZD derivative; Non-racemic thiazolidinedione intermediate; Pharmaceutical intermediate 105355-33-7.
EINECS	Contact for details

Quality Control

Our 5-(4-(2-(3-Methylpyridin-2-Yl)Ethoxy)Benzyl)Thiazolidine-2,4-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.