Description

Pioglitazone is a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), primarily used as an active pharmaceutical ingredient (API). This compound is critical for the formulation of anti-diabetic medications that help manage type 2 diabetes by improving insulin sensitivity. It is essential for pharmaceutical manufacturers and research institutions engaged in metabolic disorder therapeutics and drug development.

Application

• Pharmaceutical API: Primary use as the active ingredient in anti-diabetic medications for the treatment of type 2 diabetes mellitus.
• Research & Development: Used in biochemical and pharmacological studies to investigate PPARγ pathways and insulin sensitization mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Formulation Development: Employed in the development and scale-up of solid oral dosage forms such as tablets.
• Metabolic Disorder Research: A key tool in academic and industrial research focused on obesity, metabolic syndrome, and related disorders.

Basic Information

Item	Detail
Product Name	Pioglitazone
CAS No.	105355-27-9
Molecular Formula	C19H20N2O3S
Molecular Weight	356.44 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; AD-4833; U-72107; Actos (Brand Name); Pioglitazone Hydrochloride (Salt Form); Glustin; Zactos; TZD Derivative
EINECS	Contact for details

Quality Control

Our Pioglitazone is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.