Description

(5R)-2,3,4,5-Tetrahydro-8-Fluoro-3-Methyl-5α-Phenyl-1H-3-Benzazepin-7-Ol CAS NO 105301-41-5 is a high-purity, fluorinated benzazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral intermediate or reference standard for the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation neuropharmacological drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel dopaminergic or serotonergic receptor ligands.
• Reference Standard: Used in analytical method development, validation, and quality control for drug substance and product testing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize potency and selectivity for neurological targets.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing routes.
• Biochemical Research: Utilized as a tool compound in receptor binding assays and other in vitro pharmacological studies.

Basic Information

Product Name	(5R)-2,3,4,5-Tetrahydro-8-Fluoro-3-Methyl-5α-Phenyl-1H-3-Benzazepin-7-Ol
CAS No.	105301-41-5
Molecular Formula	C18H20FNO
Molecular Weight	285.36 g/mol
Synonyms	(5R)-8-Fluoro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol; (R)-8-Fluoro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol; 105301-41-5; 8-Fluoro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol (5R)-; 1H-3-Benzazepin-7-ol, 2,3,4,5-tetrahydro-8-fluoro-3-methyl-5-phenyl-, (5R)-
EINECS	Contact for details

Quality Control

Our (5R)-2,3,4,5-Tetrahydro-8-Fluoro-3-Methyl-5α-Phenyl-1H-3-Benzazepin-7-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; handle and store under inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.