Description

8''-Hydroxypactamycin is a structurally complex, bioactive natural product derivative of pactamycin, a known antibiotic and antitumor agent. This compound is of significant interest in pharmaceutical research and development due to its potential as a key intermediate or lead structure for novel therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new antibiotics, anticancer agents, and other bioactive small molecules. The compound offers a valuable chemical scaffold for structure-activity relationship (SAR) studies and medicinal chemistry optimization.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or lead compound in the synthesis and development of novel antibiotic and antitumor agents.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies to explore modifications that enhance potency, selectivity, or reduce toxicity.
• Biochemical Research: Employed as a tool compound to study biological pathways, particularly those related to protein synthesis inhibition in prokaryotic and eukaryotic cells.
• Anticancer Agent Discovery: Investigated for its cytotoxic properties and potential mechanisms of action against various cancer cell lines.
• Antimicrobial Discovery: Evaluated as a precursor for developing new classes of antibiotics to address drug-resistant bacterial infections.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis, natural product chemistry, and chemical biology.

Basic Information

Product Name	8''-Hydroxypactamycin
CAS No.	104820-97-5
Molecular Formula	C₂₈H₃₈N₂O₁₀
Molecular Weight	562.61 g/mol
Synonyms	8''-Hydroxy-pactamycin; Pactamycin, 8''-hydroxy-; 8''-OH-Pactamycin; 8-Hydroxypactamycin; Hydroxypactamycin; 8''-Dehydroxypactamycin derivative; Antibiotic U-22956 derivative
EINECS	Contact for details

Quality Control

Our 8''-Hydroxypactamycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records. We support research standards and can provide material tailored to your project's specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to reach room temperature in a desiccator before opening to minimize exposure to condensation. The compound should be considered moisture-sensitive and handled under an inert atmosphere for prolonged manipulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.