Description

1-Cbz-4-(2-Aminoethyl)Piperazine is a versatile, bifunctional piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its dual functionality, featuring a carboxybenzyl (Cbz) protecting group and a primary amine, enabling precise and sequential chemical modifications. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), complex heterocyclic compounds, and specialized polymers. Its reliable performance makes it a key intermediate for medicinal chemistry and custom synthesis projects.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting neurological and oncological pathways.
• Peptide Chemistry: Used as a spacer or linker unit in solid-phase peptide synthesis (SPPS) and for constructing peptide mimetics.
• Protecting Group Strategy: The Cbz group provides orthogonal protection for amines, facilitating multi-step synthetic sequences common in complex molecule assembly.
• Ligand and Catalyst Development: Serves as a backbone for creating chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer Science: Incorporated as a monomer or cross-linking agent to produce functionalized polymers with specific amine-reactive sites.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme inhibition.

Basic Information

Product Name	1-Cbz-4-(2-Aminoethyl)Piperazine
CAS No.	104740-55-8
Molecular Formula	C14H21N3O2
Molecular Weight	263.34 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(2-aminoethyl)piperazine; 4-(2-Aminoethyl)-1-Cbz-piperazine; N-Carbobenzoxy-4-(2-aminoethyl)piperazine; 1-Cbz-4-(2-Aminoethyl)piperazine; Benzyl 4-(2-aminoethyl)piperazine-1-carboxylate; 1-(Benzyloxycarbonyl)-4-(2-aminoethyl)piperazine; Piperazine, 1-[(phenylmethoxy)carbonyl]-4-(2-aminoethyl)-; 1-Cbz-4-(2-AE)piperazine
EINECS	Contact for details

Quality Control

Our 1-Cbz-4-(2-Aminoethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.