Description

Hydroxypropentofylline is a specialized xanthine derivative chemical compound with significant pharmacological research interest. Its primary value lies in its potential as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents targeting cardiovascular and neurological pathways. This product is essential for pharmaceutical R&D laboratories, fine chemical synthesis facilities, and academic institutions engaged in medicinal chemistry and drug discovery programs. We supply high-purity grades to meet the stringent demands of advanced research and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced drug candidates, particularly those with vasodilatory or neuroprotective properties.
• Medicinal Chemistry Research: Used as a reference standard or starting material in structure-activity relationship (SAR) studies to optimize therapeutic efficacy and safety profiles.
• API Development: Investigated for its potential as an active pharmaceutical ingredient in formulations targeting conditions like peripheral vascular disease or cognitive disorders.
• Biochemical Research: Employed in in-vitro and in-vivo studies to understand its mechanism of action on adenosine receptors and phosphodiesterase inhibition.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating novel xanthine-based analogs with modified biological activity.
• Reference Standard: Provides a high-purity compound for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Product Name	Hydroxypropentofylline
CAS No.	104317-70-6
Molecular Formula	C₁₃H₁₈N₄O₃
Molecular Weight	278.31 g/mol
Synonyms	1-(5-Hydroxy-5-methylhexyl)-3-methyl-7-propylxanthine; Propentofylline Hydroxy Analog; HWA 285; 3,7-Dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-7-propyl-1H-purine-2,6-dione; 1-(5-Hydroxy-5-methylhexyl)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione; Hydroxy-propentofylline
EINECS	Contact for details

Quality Control

Our Hydroxypropentofylline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.