Description

3-Endo-Aminobicyclo[2.2.1]heptane-2-endo-carboxylic acid monohydrate is a high-purity, functionalized bicyclic building block of significant interest in advanced organic synthesis. Its rigid, three-dimensional structure and dual functional groups make it a valuable scaffold for constructing complex molecules with specific stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its bicyclic framework can contribute to unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioisosteres: Its structure is valuable for creating conformationally restricted analogs of peptides to improve metabolic stability and potency.
• Academic and Industrial R&D: Employed in chemical research for method development and exploring new chemical space in heterocyclic and bridged-ring chemistry.
• Material Science Precursor: Potential use in synthesizing specialized monomers for polymers with unique thermal or mechanical properties.

Basic Information

Product Name	3-Endo-Aminobicyclo[2.2.1]heptane-2-Endo-Carboxylic Acid Monohydrate
CAS No.	104308-53-4
Molecular Formula	C8H13NO2 • H2O
Molecular Weight	173.20 g/mol (Monohydrate)
Synonyms	2-Carboxy-3-aminonorbornane monohydrate; (1R,2R,3S,4S)-3-Aminobicyclo[2.2.1]heptane-2-carboxylic acid monohydrate; 3-Amino-2-norbornanecarboxylic acid monohydrate; endo-3-Aminobicyclo[2.2.1]heptane-2-endo-carboxylic acid hydrate; 3-ABCA monohydrate; 2-Norbornane-3-amino-2-carboxylic acid monohydrate; Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-amino-, monohydrate, (1R,2R,3S,4S)-
EINECS	Contact for details

Quality Control

Our 3-Endo-Aminobicyclo[2.2.1]heptane-2-endo-carboxylic acid monohydrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	9.0 - 11.0% (Theoretical for monohydrate: ~10.4%)
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.