Description

Anguibactin is a naturally derived cyclic depsipeptide antibiotic with potent activity against Gram-positive bacteria, including multidrug-resistant strains. It serves as a critical research tool for antimicrobial mechanism studies, resistance profiling, and novel antibiotic scaffold development. Pharmaceutical R&D laboratories, academic microbiology departments, and contract research organizations (CROs) rely on high-purity Anguibactin CAS NO 104245-09-2 for target validation and preclinical screening.

Application

• Antibiotic mode-of-action studies targeting bacterial membrane integrity and cell wall biosynthesis
• Lead compound optimization in medicinal chemistry programs for next-generation anti-staphylococcal agents
• In vitro susceptibility testing (MIC/MBC determination) against Staphylococcus aureus, Enterococcus faecium, and other Gram-positive pathogens
• Reference standard in HPLC and LC-MS/MS analytical method development and validation
• Investigation of efflux pump inhibition and synergy with β-lactams or glycopeptides
• Structural biology applications including X-ray crystallography and NMR conformational analysis
• Quality control reference material for fermentation-derived antibiotic batches

Basic Information

Product Name	Anguibactin
CAS No.	104245-09-2
Molecular Formula	C56H84N10O16
Molecular Weight	1153.33 g/mol
Synonyms	Anguibactin A; Anguibactin I; RP 71955; RP-71955; Antibiotic RP-71955; Cyclo-(D-Val-L-Leu-D-allo-Ile-L-Val-D-Val-L-Leu-D-allo-Ile-L-Val); Depsipeptide antibiotic RP-71955; [D-Val1,L-Leu2,D-allo-Ile3,L-Val4,D-Val5,L-Leu6,D-allo-Ile7,L-Val8]-Anguibactin
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), and absence of specified impurities (residual solvents, heavy metals, endotoxins). Testing follows USP & EP general chapters where applicable, and all materials are manufactured under ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5–101.0%
Related Substances	≤1.5% total impurities
Residual Solvents (by GC)	Meets ICH Q3C limits
Water Content (KF)	≤5.0%
Heavy Metals	≤10 ppm
Endotoxins	<0.5 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.