Description

(3S,6S)-1,4-Dihydroxy-3-Isopropyl-6-[(R)-1-Methylpropyl]-2,5-Piperazinedione is a high-purity, stereochemically defined diketopiperazine derivative. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is essential for research and production in medicinal chemistry, serving scientists and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries. The product is supplied under strict quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a constrained scaffold or building block in drug discovery programs for structure-activity relationship (SAR) studies.
• Peptidomimetics Development: Serves as a core structure for designing and synthesizing peptidomimetic compounds that mimic natural peptides.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective catalytic reactions to construct complex molecular architectures.
• Bioconjugation & Probe Synthesis: Useful for creating labeled compounds or conjugates for biochemical and diagnostic applications.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals and advanced materials.

Basic Information

Product Name	(3S,6S)-1,4-Dihydroxy-3-Isopropyl-6-[(R)-1-Methylpropyl]-2,5-Piperazinedione
CAS No.	104187-49-7
Molecular Formula	C11H20N2O4
Molecular Weight	244.29 g/mol
Synonyms	(3S,6S)-3-Isopropyl-6-[(1R)-1-methylpropyl]-2,5-dioxopiperazine-1,4-diol; (3S,6S)-1,4-Dihydroxy-3-isopropyl-6-[(1R)-1-methylpropyl]piperazine-2,5-dione; Cyclo(L-hydroxy-D-isoleucyl-L-hydroxy-D-isoleucyl); D-Hydroxyisoleucine diketopiperazine; (3S,6S)-HID; DKPs; Diketopiperazine derivative; Cyclic dipeptide of D-hydroxyisoleucine
EINECS	Contact for details

Quality Control

Our (3S,6S)-1,4-Dihydroxy-3-Isopropyl-6-[(R)-1-Methylpropyl]-2,5-Piperazinedione is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral integrity is provided with each shipment. We adhere to cGMP principles where applicable to guarantee reliable supply and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.