Description

(3S,6S)-1,4-Dihydroxy-3,6-Diisopropyl-2,5-Piperazinedione is a chiral diketopiperazine derivative, a key structural motif in medicinal chemistry and asymmetric synthesis. This compound matters as a versatile chiral building block and intermediate for the development of pharmaceuticals, particularly in the synthesis of complex molecules like protease inhibitors and other bioactive agents. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in the creation of novel therapeutic candidates and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Asymmetric Catalyst Ligand Precursor: Used in the development of chiral ligands for metal-catalyzed asymmetric reactions, enhancing enantioselectivity.
• Peptidomimetic Research: Acts as a constrained scaffold in peptidomimetics to improve metabolic stability and bioavailability of peptide-based drug candidates.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce chiral complexity into target molecules for agrochemicals and advanced materials.
• Academic & Industrial R&D: A valuable reagent for method development in organic chemistry and for exploring new reaction pathways in process chemistry.

Basic Information

Product Name	(3S,6S)-1,4-Dihydroxy-3,6-Diisopropyl-2,5-Piperazinedione
CAS No.	104187-48-6
Molecular Formula	C10H16N2O4
Molecular Weight	228.25 g/mol
Synonyms	(3S,6S)-3,6-Diisopropyl-1,4-dihydroxy-2,5-piperazinedione; (3S,6S)-3,6-Diisopropylpiperazine-2,5-dione-1,4-diol; (S,S)-1,4-Dihydroxy-3,6-diisopropyl-2,5-piperazinedione; (S,S)-HODIP; Cyclo[(S)-β-hydroxyvaline-(S)-β-hydroxyvaline]; (S,S)-Cyclo(β-hydroxyvaline-β-hydroxyvaline); Chiral diketopiperazine derivative; (S,S)-Diisopropyl DKP diol
EINECS	Contact for details

Quality Control

Our (3S,6S)-1,4-Dihydroxy-3,6-Diisopropyl-2,5-Piperazinedione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.