Description

Tussilagone is a bioactive sesquiterpenoid compound, a key marker constituent of the traditional medicinal herb *Tussilago farfara* (Coltsfoot). This high-purity reference standard is essential for research, quality control, and product development where precise chemical identity and activity are critical. It is primarily utilized by the pharmaceutical, nutraceutical, and botanical extract industries for analytical and formulation purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Tussilagone in raw materials, extracts, and finished products.
• Bioactivity Research: Serves as a key compound in pharmacological studies investigating anti-inflammatory, anti-tussive (cough suppressant), and neuroprotective effects.
• Herbal Extract Standardization: Critical for the quality control and standardization of *Tussilago farfara* (Coltsfoot) extracts to ensure consistent potency and efficacy.
• Analytical Method Development: Employed in developing and validating HPLC, UPLC, and LC-MS methods for natural product analysis.
• Dietary Supplement Formulation: Used in the development of standardized herbal supplements targeting respiratory health.
• Academic and Clinical Research: Provides a pure compound for in-vitro and in-vivo studies to elucidate mechanisms of action and therapeutic potential.

Basic Information

Product Name	Tussilagone
CAS No.	104012-37-5
Molecular Formula	C23H34O5
Molecular Weight	390.52 g/mol
Synonyms	(-)-Tussilagone; Tussilagon; (3R,4aR,5S,6R,8aR)-5-[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]-6-hydroxy-5,6,8a-trimethyl-3-(2-methylpropanoyl)oxy-4,4a,5,6,7,8-hexahydro-3H-naphthalene-1-carboxylic acid methyl ester; Coltsfoot Lactone (related); Farfaratin (related compound).
EINECS	Contact for details

Quality Control

Our Tussilagone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.