Description

Fasudil is a potent and selective inhibitor of Rho-associated protein kinase (ROCK), a key enzyme involved in the regulation of the actin cytoskeleton and smooth muscle contraction. This mechanism of action makes it a critical research tool and a valuable intermediate in the development of therapeutics targeting cardiovascular and neurological disorders. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for applications in vasospasm, pulmonary hypertension, and neuroprotection studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and intermediate in the synthesis of novel ROCK inhibitors for cardiovascular and cerebrovascular diseases.
• Biochemical Assay Development: Used as a selective ROCK inhibitor to study Rho/ROCK signaling pathways in cell biology and pharmacology.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical building block or the final active substance in the production of investigational drugs.
• Academic & Preclinical Studies: Employed in animal models and in vitro experiments to investigate mechanisms related to vasodilation, neuroprotection, and fibrosis.
• Diagnostic Reagent Formulation: Potential use in the development of assay kits for studying endothelial function and vascular reactivity.

Basic Information

Product Name	Fasudil
CAS No.	103745-39-7
Molecular Formula	C14H17N3O2S
Molecular Weight	291.37 g/mol
Synonyms	Fasudil Hydrochloride (common salt form); HA-1077; AT-877; 5-Isoquinolinesulfonamide, 1-(5-isoquinolinylsulfonyl)homopiperazine; 1-(5-Isoquinolinesulfonyl)homopiperazine; Fasudil HCl; HA 1077 Dihydrochloride; ERIL
EINECS	Contact for details

Quality Control

Our Fasudil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed for research and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.