Description

22-Dehydro-1,25-Dihydroxy-24-Homovitamin D3 is a synthetic, biologically active vitamin D analog with a modified side chain. This compound is significant for its role as a key intermediate and reference standard in pharmaceutical research and development, particularly for studying vitamin D receptor (VDR) activity and metabolism. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers focused on endocrinology, bone health, and novel therapeutic agent synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced vitamin D analogs and prodrugs.
• Biochemical Research: Used as a reference standard in studies of vitamin D receptor (VDR) binding affinity, gene regulation, and metabolic pathways.
• Metabolite Analysis: Serves as an analytical standard in LC-MS and HPLC methods for quantifying vitamin D metabolites in biological samples.
• Drug Discovery: Employed in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutics for osteoporosis, psoriasis, and hyperparathyroidism.
• Academic Research: Utilized in university and institutional labs for fundamental research into calcium homeostasis and endocrine signaling.
• Fine Chemical Synthesis: A high-purity starting material for custom synthesis and contract manufacturing of specialized steroidal compounds.

Basic Information

Item	Details
Product Name	22-Dehydro-1,25-Dihydroxy-24-Homovitamin D3
CAS No.	103732-08-7
Molecular Formula	C₂₈H₄₂O₃
Molecular Weight	426.64 g/mol
Synonyms	1,25-Dihydroxy-22-dehydro-24-homovitamin D3; 24-Homo-22-dehydro-1,25-dihydroxyvitamin D3; 1α,25-Dihydroxy-22-dehydro-24-homocholecalciferol; 22-Dehydro-1α,25-dihydroxy-24-homovitamin D₃; (5Z,7E)-9,10-Secocholesta-5,7,10(19),22-tetraene-1α,3β,25-triol (24-homo derivative); 24-Homo-22-dehydrocalcitriol; Vitamin D analog 103732-08-7
EINECS	Contact for details

Quality Control

Our 22-Dehydro-1,25-Dihydroxy-24-Homovitamin D3 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.