Description

6-(1-Hydroxyethyl)-2-(1-Acetimidoylpyrrolidin-3-Ylthio)-1-Methyl-1-Carbapen-2-Em-3-Carboxylic Acid is a key advanced pharmaceutical intermediate in the carbapenem class of β-lactam antibiotics. This compound is critical for the synthesis of next-generation broad-spectrum antibiotics, offering enhanced stability and potency against resistant bacterial strains. It is primarily required by pharmaceutical R&D laboratories and API manufacturers engaged in the development and production of sophisticated anti-infective therapies.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for the manufacture of novel carbapenem antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for designing and testing new antibacterial agents with improved efficacy.
• Process Chemistry & Scale-Up: Serves as a critical building block in optimizing synthetic routes for commercial antibiotic production.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions.
• Antibacterial Mechanism Studies: Utilized in biochemical research to investigate the interaction of carbapenems with bacterial penicillin-binding proteins.

Basic Information

Product Name	6-(1-Hydroxyethyl)-2-(1-Acetimidoylpyrrolidin-3-Ylthio)-1-Methyl-1-Carbapen-2-Em-3-Carboxylic Acid
CAS No.	103730-44-5
Molecular Formula	C16H23N3O5S
Molecular Weight	369.44 g/mol
Synonyms	(5R,6S)-6-[(1R)-1-Hydroxyethyl]-2-[[(3S)-1-(1-Iminoethyl)-3-pyrrolidinyl]thio]-1-methyl-1-carbapen-2-em-3-carboxylic Acid; (5R,6S)-2-[(3S)-1-Acetimidoyl-3-pyrrolidinylthio]-6-(1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylic Acid; Carbapenem Intermediate 103730-44-5; 1-Methyl-6-(1-hydroxyethyl)-2-[(3S)-1-(1-iminoethyl)-3-pyrrolidinylthio]-1-carbapen-2-em-3-carboxylic Acid; L-627, Intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical methods including HPLC, NMR, and MS to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with client-specific or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment and opened under anhydrous conditions when handling.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.