Description

24-Homo-1,25-Dihydroxyvitamin D3 is a synthetic analog of the biologically active form of vitamin D, designed for advanced research and development applications. This compound is valued for its specific structural modifications, which allow researchers to probe and modulate vitamin D receptor (VDR) signaling pathways with high precision. It is primarily utilized by pharmaceutical R&D teams, academic institutions, and fine chemical manufacturers focused on endocrinology, oncology, and metabolic disease research.

Application

• Pharmaceutical Research & Development: A key reference standard and intermediate in the synthesis of novel vitamin D receptor (VDR) modulators for therapeutic applications.
• Biochemical Studies: Used to investigate the structure-activity relationship (SAR) of vitamin D analogs and their interaction with the VDR.
• Cell Biology & Signaling Research: Employed in *in vitro* and cellular assays to study the effects of VDR activation on cell differentiation, proliferation, and apoptosis.
• Metabolic Disorder Research: A tool compound for exploring potential treatments for conditions related to calcium homeostasis and bone metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Fine Chemical Synthesis: An advanced intermediate for the custom synthesis of more complex, target-specific vitamin D analogs.

Basic Information

Product Name	24-Homo-1,25-Dihydroxyvitamin D3
CAS No.	103656-40-2
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.65 g/mol
Synonyms	24-Homo-1,25-dihydroxycholecalciferol; 24-Homo-calcitriol; 1α,25-Dihydroxy-24-homovitamin D₃; 24-Homo-1α,25-dihydroxyvitamin D₃; 24-Homo-1,25-(OH)₂D₃; 24-Homo-1,25-dihydroxyvitamin D₃; 24-Homo-1,25-D₃; 24-Homo-1,25-dihydroxycholecalciferol
EINECS	Contact for details

Quality Control

Our 24-Homo-1,25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.