Description

2-Fluorovitamin D3 is a fluorinated analog of Vitamin D3, designed to enhance metabolic stability and biological activity. This compound is critical for advanced research and development in pharmaceuticals, particularly for studying Vitamin D receptor (VDR) pathways and developing novel therapeutics. It is primarily utilized by research institutions and pharmaceutical companies focused on metabolic bone diseases, cancer research, and the development of new hormone analogs.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis of novel Vitamin D analogs for therapeutic applications.
• Biochemical Studies: Used to investigate the structure-activity relationship (SAR) of Vitamin D derivatives and their interaction with the VDR.
• Metabolic Pathway Analysis: Employed in metabolic studies to understand the stability and effects of fluorinated sterols in biological systems.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of related pharmaceutical compounds.
• Preclinical Development: Utilized in the early-stage development of drugs targeting osteoporosis, psoriasis, and certain cancers.

Basic Information

Product Name	2-Fluorovitamin D3
CAS No.	103638-37-5
Molecular Formula	C₂₇H₄₃FO
Molecular Weight	402.63 g/mol
Synonyms	(5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3β-ol, 2-fluoro-; 2-Fluoro-9,10-secocholesta-5,7,10(19)-trien-3β-ol; 2-Fluoro-cholecalciferol; 2-Fluoro-Vitamin D3; 2-F-D3; 2-Fluorocalciol; 2-Fluorocalciferol
EINECS	Contact for details

Quality Control

Our 2-Fluorovitamin D3 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While not intended for direct human use, production adheres to principles of current Good Manufacturing Practice (cGMP) where applicable for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.