Description

(2S,3R,4E)-n-Tetracosanoyl Sphingosine CAS NO 102917-80-6 is a high-purity, synthetic sphingolipid derivative, specifically a C24-ceramide. This compound serves as a critical reference standard and building block in advanced lipidomics research and the development of bioactive formulations. It is essential for researchers and manufacturers in the pharmaceutical, cosmetic, and life science industries who require structurally defined, high-quality lipids for studying cell signaling, skin barrier function, and metabolic pathways.

Application

• Biomedical Research: As a reference standard for the quantification and identification of ceramides in mass spectrometry-based lipidomic studies.
• Pharmaceutical Development: A key intermediate in the synthesis of novel sphingolipid-based therapeutics targeting apoptosis, inflammation, and cancer.
• Cosmetic Science: Used in R&D for formulating high-performance skincare products aimed at restoring and enhancing the skin's natural lipid barrier.
• Cell Biology Studies: Employed to investigate the role of specific ceramide species in cellular processes like differentiation, senescence, and stress response.
• Biochemical Reagent: Serves as a substrate or inhibitor in enzymatic assays for sphingolipid metabolism (e.g., ceramidases, sphingomyelin synthases).
• Drug Delivery Systems: Investigated as a component in lipid nanoparticles (LNPs) and other advanced delivery vehicles for improved bioavailability.

Basic Information

Product Name	(2S,3R,4E)-n-Tetracosanoyl Sphingosine
CAS No.	102917-80-6
Molecular Formula	C46H91NO3
Molecular Weight	706.2 g/mol
Synonyms	N-Lignoceroyl-D-erythro-sphingosine; Ceramide (d18:1/24:0); C24:0 Ceramide; N-(Tetracosanoyl)-sphing-4-enine; D-erythro-C24-Ceramide; Lignoceroyl sphingosine; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(tetracosanoate); N-Lignoceroylsphingosine
EINECS	Contact for details

Quality Control

Every batch of (2S,3R,4E)-n-Tetracosanoyl Sphingosine is produced and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced analytical techniques such as HPLC, NMR, and MS to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.