Description

5,12,20-Trihydroxy-8,10,14-Eicosatrienoic Acid is a specialized polyhydroxy fatty acid derivative with a unique conjugated triene structure. This compound serves as a critical intermediate and reference standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by research institutions and manufacturers in the life sciences sector focusing on lipidomics, inflammation pathways, and the synthesis of bioactive eicosanoids.

Application

• Biochemical Research Standard: Used as a high-purity reference compound in lipidomics and eicosanoid research for method development and calibration.
• Pharmaceutical Intermediate: Serves as a key synthetic building block for the development of novel anti-inflammatory and pro-resolving lipid mediators.
• Cell Signaling Studies: Employed in vitro and in vivo studies to investigate the role of hydroxy fatty acids in cellular communication and metabolic pathways.
• Enzyme Substrate/Inhibitor: Acts as a substrate for lipoxygenase and cytochrome P450 enzyme studies to elucidate reaction mechanisms and kinetics.
• Analytical Method Development: Essential for developing and validating LC-MS/MS, HPLC, and GC-MS methods for the detection and quantification of complex lipids.

Basic Information

Product Name	5,12,20-Trihydroxy-8,10,14-Eicosatrienoic Acid
CAS No.	102910-24-7
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	5,12,20-TriHETE; (8E,10E,14Z)-5,12,20-Trihydroxyicosa-8,10,14-trienoic acid; 5,12,20-Trihydroxyeicosatrienoic Acid; 5,12,20-THETA; 5,12,20-Trihydroxy-8,10,14-eicosatrienoate; 20-Hydroxy-5,12-diHETE; 5,12,20-Trihydroxyicosatrienoic Acid
EINECS	Contact for details

Quality Control

Every batch of 5,12,20-Trihydroxy-8,10,14-Eicosatrienoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products are supported by a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and consistency for critical research applications. We adhere to cGMP principles for laboratory chemicals to guarantee reliability and reproducibility in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer environment. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.