Description

2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphorodiamidite is a high-purity phosphoramidite monomer, a critical building block in automated oligonucleotide synthesis. Its primary value lies in enabling the efficient and scalable production of DNA and RNA sequences, including primers, probes, and antisense oligonucleotides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and molecular diagnostics industries who require reliable, high-quality reagents for nucleic acid synthesis.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer in solid-phase automated synthesis of DNA and RNA strands.
• Therapeutic Development: For the production of antisense oligonucleotides, siRNA, and aptamers used in drug discovery and development.
• Molecular Diagnostics: Manufacturing of primers and probes for PCR, qPCR, and next-generation sequencing applications.
• Research Reagents: Used in academic and industrial laboratories for custom gene synthesis and molecular biology research.
• Bioconjugation: Serving as an intermediate for the synthesis of labeled nucleotides and other modified nucleic acids.

Basic Information

Product Name	2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphorodiamidite
CAS No.	102691-36-1
Molecular Formula	C16H34N3O2P
Molecular Weight	331.44 g/mol
Synonyms	2-Cyanoethyl Tetraisopropylphosphorodiamidite; CE-TIPA Phosphoramidite; N,N,N',N'-Tetraisopropyl-O-(2-cyanoethyl)phosphorodiamidite; Tetraisopropyl 2-cyanoethyl phosphorodiamidite; Phosphorodiamidous acid, N,N,N',N'-tetraisopropyl-, 2-cyanoethyl ester; Amidite CE-TIPA; DNA Synthesis Monomer CE-TIPA
EINECS	Contact for details

Quality Control

Our 2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphorodiamidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can provide material traceable to relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture must be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.1%
31P NMR	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.