Description

4-(4-Acetyl-Piperazin-1-Yl)-2-Chloroaniline is a high-purity, functionalized aniline derivative featuring a piperazine-acetyl pharmacophore. This compound is a critical pharmaceutical intermediate valued for its role in synthesizing complex molecules with targeted biological activity. It is primarily required by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its chloroaniline core.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production scale-up of APIs containing functionalized piperazine motifs.
• Ligand and Catalyst Preparation: Potential precursor for creating specialized ligands used in catalytic processes.
• Fine Chemical Production: Intermediate for other high-value, specialty chemicals requiring precise molecular architecture.

Basic Information

Product Name	4-(4-Acetyl-Piperazin-1-Yl)-2-Chloroaniline
CAS No.	101970-41-6
Molecular Formula	C12H16ClN3O
Molecular Weight	253.73 g/mol
Synonyms	2-Chloro-4-(4-acetylpiperazin-1-yl)aniline; 1-[4-Amino-3-chlorophenyl]-4-acetylpiperazine; 4-(4-Acetyl-1-piperazinyl)-2-chloroaniline; 2-Chloro-4-(4-acetyl-1-piperazinyl)benzenamine; N-(3-Chloro-4-aminophenyl)-N'-acetylpiperazine; 4-Acetyl-1-(4-amino-3-chlorophenyl)piperazine; 101970-41-6; 2-Chloro-4-(4-acetylpiperazin-1-yl)phenylamine
EINECS	Contact for details

Quality Control

Our 4-(4-Acetyl-Piperazin-1-Yl)-2-Chloroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.