Description

(2R,3S)-Piperazine-2,3-Dicarboxylic Acid Dimethyl Ester CAS NO 101269-52-7 is a high-purity, stereochemically defined chiral piperazine derivative, serving as a critical building block in advanced organic synthesis. Its precise stereochemistry makes it an invaluable intermediate for constructing complex molecules with defined three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with specific stereochemical requirements for enhanced activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics: Incorporated into the backbone of peptide analogs to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Academic & Process R&D: A valuable reagent for methodological development in stereoselective synthesis and scale-up process optimization.

Basic Information

Product Name	(2R,3S)-Piperazine-2,3-Dicarboxylic Acid Dimethyl Ester
CAS No.	101269-52-7
Molecular Formula	C8H14N2O4
Molecular Weight	202.21 g/mol
Synonyms	(2R,3S)-2,3-Dimethoxycarbonylpiperazine; (2R,3S)-Piperazine-2,3-dicarboxylic acid dimethyl ester; Dimethyl (2R,3S)-piperazine-2,3-dicarboxylate; (2R,3S)-2,3-Piperazinedicarboxylic acid dimethyl ester; (2R,3S)-1,4-Diazinane-2,3-dicarboxylic acid dimethyl ester; (2R,3S)-Hexahydropyrazine-2,3-dicarboxylic acid dimethyl ester; (2R,3S)-DMCP
EINECS	Contact for details

Quality Control

Our (2R,3S)-Piperazine-2,3-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.