Description

Phorbol 13-Butyrate, 4Beta is a specific, high-purity derivative of the phorbol ester family, a class of compounds known for their potent biological activity. This compound is critical for advanced biomedical research, particularly in the study of protein kinase C (PKC) signaling pathways and cellular mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, immunology, and dermatology.

Application

• Biomedical Research: A key tool compound for activating Protein Kinase C (PKC) isoforms in cell-based assays and mechanistic studies.
• Oncology Studies: Used to investigate tumor promotion, cell proliferation, and apoptosis in cancer research models.
• Immunology Research: Employed to study T-cell activation, cytokine production, and inflammatory responses.
• Signal Transduction Analysis: Essential for elucidating downstream effects of PKC activation on various cellular pathways.
• Dermatological Research: Applied in studies of skin inflammation and hyperproliferative disorders.
• Pharmacology: Serves as a reference standard and positive control in drug discovery screening against PKC targets.

Basic Information

Product Name	Phorbol 13-Butyrate, 4Beta
CAS No.	100929-94-0
Molecular Formula	C28H38O8
Molecular Weight	502.60 g/mol
Synonyms	4β-Phorbol 13-butyrate; 4β-Phorbol 13-butyrate; 12-O-Tetradecanoylphorbol-13-butyrate (TPB) analog; Phorbol 13-butyrate; 4β-PDB; 4β-Phorbol-12,13-dibutyrate derivative; PKC Activator (4β-isomer); 1,1a,1b,4,4a,7a,7b,8,9,9a-Decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 13-butyrate 4-benzoate
EINECS	Contact for details

Quality Control

Our Phorbol 13-Butyrate, 4Beta is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.