Description

8-Hydroperoxyeicosatetraenoic Acid is a specialized bioactive lipid metabolite derived from arachidonic acid. This compound is a critical intermediate in the lipoxygenase pathway, playing a significant role in cellular signaling and inflammatory response mechanisms. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for biochemical research, drug discovery, and as a reference standard in analytical studies.

Application

• Biochemical Research: Used as a key intermediate and substrate in studies of eicosanoid biosynthesis, lipid peroxidation, and the lipoxygenase enzyme pathway.
• Pharmaceutical R&D: Serves as a reference standard and a critical reagent in the development of drugs targeting inflammatory diseases, such as asthma, arthritis, and atherosclerosis.
• Cell Signaling Studies: Employed to investigate the role of lipid hydroperoxides in cellular signaling cascades, oxidative stress responses, and apoptosis.
• Analytical Chemistry: Used as a high-purity calibration standard in chromatographic (HPLC, LC-MS) and spectroscopic analyses for accurate quantification in complex biological matrices.
• Enzymology: Acts as a specific substrate for studying the activity and inhibition of lipoxygenase enzymes.
• Cosmeceutical Research: Investigated for its role in skin inflammation and oxidative damage models, supporting the development of advanced dermatological products.

Basic Information

Product Name	8-Hydroperoxyeicosatetraenoic Acid
CAS No.	100896-35-3
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	8-HPETE; 8(S)-HPETE; (5Z,9E,11Z,14Z)-8-Hydroperoxyicosa-5,9,11,14-tetraenoic Acid; 8-Hydroperoxy-5,9,11,14-eicosatetraenoic Acid; 8(S)-Hydroperoxyeicosatetraenoic Acid; Arachidonic Acid 8-Hydroperoxide; 8-Lipoxygenase Product
EINECS	Contact for details

Quality Control

Our 8-Hydroperoxyeicosatetraenoic Acid is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, guaranteeing traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen). This product is strictly light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.