Description

(4-Methyl-Piperazin-1-Yl)-(S)-Pyrrolidin-2-Yl-Methanone is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a defined stereocenter and a functionalized piperazine-pyrrolidone scaffold. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs targeting CNS, oncology, and other therapeutic areas.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Process Chemistry Development: Scaled-up for use in route scouting and optimization for the commercial manufacturing of candidate drugs.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke intermediates.

Basic Information

Product Name	(4-Methyl-Piperazin-1-Yl)-(S)-Pyrrolidin-2-Yl-Methanone
CAS No.	100158-68-7
Molecular Formula	C10H19N3O
Molecular Weight	197.28 g/mol
Synonyms	(S)-1-(4-Methylpiperazine-1-carbonyl)pyrrolidine-2-carbonitrile (related nitrile); (S)-N-(4-Methylpiperazin-1-yl)pyrrolidine-2-carboxamide; L-Proline, 1-[(4-methyl-1-piperazinyl)carbonyl]-; (S)-2-Pyrrolidinecarboxamide, N-(4-methyl-1-piperazinyl)-; 1-[(4-Methylpiperazin-1-yl)carbonyl]-(S)-pyrrolidine; (S)-1-(4-Methylpiperazine-1-carbonyl)pyrrolidine; (S)-Pyrrolidin-2-yl-(4-methylpiperazin-1-yl)methanone
EINECS	Contact for details

Quality Control

Our (4-Methyl-Piperazin-1-Yl)-(S)-Pyrrolidin-2-Yl-Methanone is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including chiral purity verification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.