Description

7-[3-(4-Butyl-1-Piperazinyl)-2-Hydroxypropyl]Theophyline is a specialized theophylline derivative, a xanthine alkaloid modified with a piperazine moiety. This structural modification is significant as it can alter the compound's pharmacological profile, potentially enhancing its selectivity or bioavailability for specific therapeutic applications. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating bronchodilatory, anti-inflammatory, or central nervous system activities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting respiratory or neurological disorders.
• Biochemical Research: Used as a reference standard or experimental compound in pharmacological studies to explore adenosine receptor antagonism.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new xanthine-based therapeutics.
• Analytical Standard: Employed in quality control laboratories for method development and validation using HPLC or LC-MS.

Basic Information

Product Name	7-[3-(4-Butyl-1-Piperazinyl)-2-Hydroxypropyl]Theophyline
CAS No.	19971-76-7
Molecular Formula	C18H29N5O3
Molecular Weight	363.46 g/mol
Synonyms	Buflomedil Theophylline; Buflomedil Theophyllinate; 7-[3-(4-Butylpiperazin-1-yl)-2-hydroxypropyl]-1,3-dimethylpurine-2,6-dione; 1,3-Dimethyl-7-[2-hydroxy-3-(4-n-butyl-1-piperazinyl)propyl]xanthine; Theophylline, 7-[3-(4-butyl-1-piperazinyl)-2-hydroxypropyl]-; Buflomedil Theophylline Salt; Buflomedil Theophylline Derivative; Buflomedil Theophylline Complex
EINECS	Contact for details

Quality Control

Our 7-[3-(4-Butyl-1-Piperazinyl)-2-Hydroxypropyl]Theophyline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets precise customer specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.