Description

Piperazine, 1-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Yl)-4-Meth Yl-, S-Oxide, (Z)-2-Butenedioate (1:1) is a high-purity, complex organic salt with significant pharmacological interest. This compound is valued for its role as a key intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the development of psychotropic and neuroactive drugs. It is essential for pharmaceutical R&D laboratories and manufacturers requiring precise, reliable building blocks for complex molecular architectures.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of tricyclic antidepressant and antipsychotic drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and scale-up production of novel central nervous system (CNS) targeting medications.
• Biochemical Research: Used in academic and industrial research to study receptor binding and structure-activity relationships (SAR) of dibenzothiepin derivatives.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Reference Standard: Suitable for use as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Piperazine, 1-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Yl)-4-Meth Yl-, S-Oxide, (Z)-2-Butenedioate (1:1)
CAS No.	19939-38-9
Molecular Formula	C23H25ClN2O2S • C4H4O4
Molecular Weight	548.99 g/mol (for the salt)
Synonyms	1-(8-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine 1-oxide fumarate; Zotepine Fumarate; Zotepine Fumarate Salt; (Z)-2-Butenedioic acid compound with 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine 1-oxide (1:1); Lodopin Impurity; Nipolept Impurity; Antipsychotic Intermediate
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(8-Chloro-10,11-Dihydrodibenzo(B,F)Thiepin-10-Yl)-4-Meth Yl-, S-Oxide, (Z)-2-Butenedioate (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings (e.g., DMF, CMC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.