Description

1H-1,4-Diazepine-1-Ethanol, Hexahydro-4-(3-(3-Chloro-10H-Pyrido(3,2-B) (1,4)Benzothiazin-10-Yl)Propyl)-, Dihydrochloride is a high-purity, complex heterocyclic compound primarily utilized as a critical pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and psychotropic medications. This product is essential for research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules targeting neurological pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for the research and development of new psychotropic and CNS-acting drugs.
• Medicinal Chemistry Research: Used in academic and industrial R&D for structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	1H-1,4-Diazepine-1-Ethanol, Hexahydro-4-(3-(3-Chloro-10H-Pyrido(3,2-B) (1,4)Benzothiazin-10-Yl)Propyl)-, Dihydrochloride
CAS No.	19824-91-0
Molecular Formula	C21H29ClN4OS · 2HCl
Molecular Weight	489.92 g/mol (for dihydrochloride salt)
Synonyms	Hexahydro-4-[3-(3-chloro-10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]-1H-1,4-diazepine-1-ethanol dihydrochloride; 10-[3-[4-(2-Hydroxyethyl)hexahydro-1H-1,4-diazepin-1-yl]propyl]-3-chloro-10H-pyrido[3,2-b][1,4]benzothiazine dihydrochloride; Clotiapine Impurity; Clotiapine Related Compound; Clotiapine Intermediate; Clotiapine Dihydrochloride Intermediate; CRM 5708; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1H-1,4-Diazepine-1-Ethanol, Hexahydro-4-(3-(3-Chloro-10H-Pyrido(3,2-B) (1,4)Benzothiazin-10-Yl)Propyl)-, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and related substances are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.