Description

Ovalicin is a naturally occurring sesquiterpene metabolite with potent biological activity, primarily known for its immunosuppressive and anti-angiogenic properties. This compound is of significant interest in pharmaceutical research and development due to its unique mechanism of action, which involves the inhibition of methionine aminopeptidase type 2 (MetAP2). It serves as a critical reference standard and a valuable building block for researchers in the fields of immunology, oncology, and medicinal chemistry, enabling the study of novel therapeutic pathways.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of immunosuppressive and anti-cancer therapies.
• Immunology Studies: Used in biochemical and cellular assays to investigate mechanisms of immune response modulation and T-cell function.
• Angiogenesis Inhibition Research: Employed in preclinical studies to explore its effects on tumor growth and metastasis by inhibiting the formation of new blood vessels.
• Medicinal Chemistry & Drug Discovery: Serves as a sophisticated scaffold or precursor for the synthesis of novel analogs with optimized pharmacological profiles.
• Biochemical Tool Compound: Utilized in enzymatic studies to specifically inhibit MetAP2, aiding in the elucidation of its role in various cellular processes.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in chemical biology and pharmacology.

Basic Information

Product Name	Ovalicin
CAS No.	19683-98-8
Molecular Formula	C₁₅H₂₂O₅
Molecular Weight	282.33 g/mol
Synonyms	(-)-Ovalicin; L-671,329; Antibiotic L 671329; Antibiotic L-671,329; 6,7-Epoxy-4,5-dihydro-3,7-dimethyl-4-(2-methyl-1-oxobutoxy)-1H-cyclopenta[c]pyran-1-one; 4,5-Dihydro-6,7-epoxy-3,7-dimethyl-4-[(2-methyl-1-oxobutyl)oxy]-1H-cyclopenta[c]pyran-1-one
EINECS	Contact for details

Quality Control

Our Ovalicin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques such as HPLC, NMR, and MS. We support research and development with material that meets the stringent standards required for pharmaceutical reference compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.