Description

Actinobolin Sulfate CAS NO 18802-17-0 is a sulfate salt form of the antibiotic actinobolin, a nucleoside analog originally isolated from *Streptomyces griseoviridus*. This compound is valued in research for its unique mechanism of action as a protein synthesis inhibitor, specifically targeting the peptidyl transferase center of the ribosome. It serves as a critical biochemical tool for researchers in microbiology, molecular biology, and pharmaceutical development studying antibiotic mechanisms, ribosomal function, and novel therapeutic pathways.

Application

• Biochemical Research: Used as a specific inhibitor of protein synthesis in prokaryotic and eukaryotic cell-free systems to study ribosomal function and translation mechanisms.
• Antimicrobial Studies: Serves as a reference standard and active agent in research focused on novel antibiotic discovery and resistance mechanisms.
• Pharmaceutical Development: Employed in early-stage drug discovery programs targeting bacterial infections, particularly for investigating structure-activity relationships (SAR) of nucleoside antibiotics.
• Microbiology & Cell Biology: Utilized in laboratory experiments to selectively inhibit protein production, allowing for the study of gene expression and cellular processes.
• Academic Research: A key reagent for universities and research institutions conducting fundamental studies in molecular genetics and enzymology.
• Standards & Controls: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Actinobolin Sulfate
CAS No.	18802-17-0
Molecular Formula	C12H19N5O7 • xH2SO4
Molecular Weight	329.31 g/mol (for actinobolin base)
Synonyms	Actinobolin sulfate salt; Antibiotic 66-40; NSC-52644; 9-β-D-Arabinofuranosyladenine sulfate derivative (actinobolin); 4-Amino-7-(β-D-arabinofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide sulfate
EINECS	Contact for details

Quality Control

Our Actinobolin Sulfate is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, identity confirmation by IR and NMR spectroscopy, and specific tests for moisture content and sulfate counterion. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results and ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 1.0%
Microbial Limits	Meets standard criteria for non-sterile products

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.